Prices start at £30 per bag and the service is operated by home baggage check-in company AirPortr.
Families can check in up to four bags from £40 and are given a three-hour pick-up slot.
The service is available from Gatwick, with other airports set to be added at a later date.
Customers book a collection slot online at airportr.com or thomascookairlines.com, the luggage is sealed and checked-in at the customer’s home, typically the day before they fly, from any address in London or the surrounding area.
AirPortr delivers the bags directly onto the customer’s flight, allowing them to travel to the airport bag-free, skip bag drop and head straight to security
Customers are kept informed on the location and status of their bags every step of the way via email and SMS and then pick the bag up from the baggage carousel in their destination airport.
Thomas Cook Airlines head of product and ancillaries Andrew Gillies said: “We are committed to innovating for our customers, so we explore anything that can make flying with us an even smoother experience.
“AirPortr allows our customers to check bags in from their own front door so they can travel easily across London without heavy baggage, travel seamlessly through the airport, enjoy their flight and start their holiday stress-free.
“We hope to expand this service with AirPortr to more of our UK departure airports in the near future.”
AirPort CEO Randel Darby said: “Home bag check-in is a perfect fit, allowing customers to start their holiday the moment they leave the house.
“Travelling without bags and skipping busy airport queues makes the whole process of going on holiday so much more enjoyable.”